Missing Spaces – hold them or close them?

Goals and responses to failure: Knowing when to hold them and when to fold them

The ability to disengage from hopeless situations is critical to goal attainment and effective selfregulation. Two experiments investigated the effects of striving to attain success (approach goals) versus striving to avoid failure (avoidance goals) on persistence. Participants completed anagrams designed so that less persistence during an initial set of unsolvable anagrams was beneficial. In S...

Wear them, forget them.

When to Hold Them: Retention of Duplicate Genes in Poplar.

In someways, your genes resemble playing cards: you work with the hand you’re dealt. Sometimes, during the course of evolution, the dealer throws a species an unusual hand that includes duplicates of a few, or all, of its genes. Indeed, in plants, singlegene and whole-genome duplications have played a major role in evolution. For cards and genes, holding too many can prove a burden, and genes c...

Off-label prescriptions: how to identify them, frame them, announce them and monitor them in practice?

Following the Mediator crisis and the passage of the Health and Safety Law of December 2011, off-label prescriptions are a real concern shared by all those involved in healthcare system. Off-label, in the strictest sense of the term, is defined as all prescriptions that do not correspond to the summary of product characteristics (SPC), particularly those that fail to comply with the indications...

Know When to Hold Them, Know When to Fold Them: Dealer Behavior in Highly Illiquid Risky Assets

This study examines dealer behavior in a sample of 14,749 corporate bonds that vary in credit rating and liquidity. Our unique data set allows us to identify purchases and sales by individual dealers, enabling us to determine how long a dealer holds a bond purchase in inventory and how much of that initial purchase the dealer sold to customers, and the spread on those sales to customers, and ho...